The Orphanage centers on Laura (Belén Rueda) who purchases her beloved childhood orphanage with dreams of restoring and reopening the long abandoned facility as a place for disabled children. Once there, Laura discovers that the new environment awakens her son's imagination, but the ongoing fantasy games he plays with an invisible friend quickly turn into something more disturbing. Upon seeing her family increasingly threatened by the strange occurrences in the house, Laura looks to a group of parapsychologists for help in unraveling the mystery that has taken over the place.